Of the 129 samples in which two semen specimens were provided within one hour, twelve (9%) had discordant results – viral load undetectable in one specimen but detectable in the other. Median viral load in the detectable samples was 918 copies/ml, and in six cases was above 1000 copies/ml.
…The study found a trend towards a higher frequency of detectable HIV in the semen of men taking protease inhibitor-based treatment.
Is it not possible that protease inhibitors are causing damage that flags as HIV and is flushed out in semen? If the samples commonly show detectable preceding undetectable then that could well be true. In other words, the drugs have an ‘effect’ for as long as they’re fully in the system.